منابع مشابه
Biomarkers in osteoarthritis.
PURPOSE OF REVIEW Osteoarthritis is a chronic disease characterized by progressive destruction of articular cartilage and subchondral bone, and synovial reaction. Clinical and radiologic findings that form the basis of the diagnosis of osteoarthritis are poorly sensitive for monitoring the progression of the disease. Biologic markers reflecting quantitative and dynamic changes of joint tissue t...
متن کاملBiomarkers in osteoarthritis
Biomarkers aid the study of osteoarthritis (OA) in a number of different ways. In this article we summarise briefly their multiple uses and reflect on how the study reported in a previous edition of Arthritis Research & Therapy should promote further investigation of cartilage oligomeric matrix protein (COMP). COMP is foremost among hitherto investigated biomarkers and is most consistently show...
متن کامل7. Biomarkers in osteoarthritis
The risk of osteoarthritis (OA), the disease stage, and its progression are generally assessed by basic pain measurements, clinical examination, and conventional X-rays. These techniques lack sensitivity in disease monitoring, especially in the early stages of disease, and need to be further developed using additional variables to optimize clinical studies and disease management. In recent year...
متن کاملBiomarkers in osteoarthritis.
Osteoarthritis (OA) can be a progressive disabling disease, which results from the pathological imbalance of degradative and reparative processes, with concomitant inflammatory changes. The synovium, bone, and cartilage are each well established sites involved in the pathophysiological mechanisms that lead to progressive joint degeneration. The search for disease-modifying osteoarthritis drugs,...
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ژورنال
عنوان ژورنال: Osteoarthritis and Cartilage
سال: 2015
ISSN: 1063-4584
DOI: 10.1016/j.joca.2015.02.009